Estimate Time2 min

A contrarian perspective on investing in biotech leaders

While some areas of the U.S. stock market are riding high on artificial intelligence, power generation and reshoring, the lagging health care sector looks appealing to Fidelity Portfolio Manager Chris Lin, particularly some biotechnology firms he feels have been unfairly penalized by a generally unfavorable outlook for the group under the current presidential administration.

“While they may not be generating attention-grabbing headlines like some other industries, I’m keeping a close watch on select pharmaceutical and biotech companies that have quietly driven innovation while addressing critical health challenges,” says Lin, who manages Fidelity® OTC Portfolio (FOCPX).

In helming the equity strategy since 2017, Lin invests primarily in dynamic growth companies listed on the Nasdaq stock exchange. In particular, he seeks firms with above-average earnings-growth potential and a sustainable business model, for which he believes the market has mispriced the rate and/or durability of growth.

By taking a contrarian approach in the health care sector, Lin tends to avoid chasing trends, focusing instead on resilient, innovative, high-quality companies that have been largely overlooked. In mid-2025, he gravitated toward several biotech stocks that seemed overly penalized despite maintaining strong business fundamentals. He was particularly bullish on recent research showing how vital regulation of the immune system is in treating a wide array of diseases.

Learn More

Interested in Fidelity® OTC Portfolio? Research FOCPX.

“If the immune system is in overdrive, it tends to lead to autoimmune conditions such as myasthenia gravis, asthma, multiple sclerosis and inflammatory bowel disorders,” Lin explains. “On the other hand, if is too weak, the result is often infection and potentially even cancer.”

Lin cites Dutch biotech firm argenx (ARGX) as revolutionizing treatment with its blockbuster drug Vyvgart®, an intravenously administered treatment for myasthenia gravis and other autoimmune diseases.

With sales of Vyvgart and its subcutaneous injection counterpart on the rise, Lin believes argenx has showcased its ability to successfully execute on its playbook.

“Furthermore, the company expects six registrational and six proof-of-concept readouts by the end of 2026, making it well-positioned to transform care for patients with high unmet needs,” he adds. Lin also highlights Legend Biotech (LEGN), a specialist in novel cell therapies for oncology that is committed to advancing cancer treatments.

When shares of the firm dropped in the months before and after the U.S. presidential election in November 2024, he saw a buying opportunity based on his view of Legend’s long-term potential.

“Investing in health care today isn’t about chasing trends, it’s about recognizing the resilience and innovation of high-quality companies that have been largely overlooked, while taking a targeted, opportunistic approach to investing in them,” concludes Lin.

For specific fund information, including full holdings, please click on the fund trading symbol above. Securities mentioned were fund investments as of January 31, 2026.

christopher-lin
Chris Lin
Portfolio Manager

Chris Lin is a portfolio manager in the Equity division at Fidelity Investments.

In this role, Mr. Lin is manager of the Fidelity OTC Portfolio and the Fidelity OTC Commingled Pool. He also manages the Information Technology sleeves for several other funds.

Prior to assuming his current responsibilities, Mr. Lin served as a research analyst responsible for the coverage of large cap internet stocks and was also the Technology Equity Research Team Sector Leader. He also previously managed Fidelity Select Computers Portfolio and co-managed Fidelity Select Semiconductors Portfolio, Fidelity Advisor Semiconductors Fund, and Fidelity Stock Selector Mid Cap Fund. He also served as a research analyst and as a research associate covering biotechnology and other health care stocks. He has been in the investment management industry since joining Fidelity in 2002.

Mr. Lin earned his bachelor of arts degree, with honors, in economics from Harvard University.

Interested in mutual funds?

Choose your criteria and get fund picks from Fidelity or independent experts.

More to explore

Before investing, consider the funds' investment objectives, risks, charges, and expenses. Contact Fidelity for a prospectus or, if available, a summary prospectus containing this information. Read it carefully.

Because of their narrow focus, sector investments tend to be more volatile than investments that diversify across many sectors and companies.

Growth stocks can perform differently from the market as a whole and other types of stocks, and can be more volatile than other types of stocks.

Value stocks can perform differently from other types of stocks, and can continue to be undervalued by the market for long periods of time.

Stock markets are volatile and can fluctuate significantly in response to company, industry, political, regulatory, market, or economic developments. Investing in stock involves risks, including the loss of principal.

Foreign investments involve greater risks than U.S. investments, including political and economic risks and the risk of currency fluctuations, all of which may be magnified in emerging markets.

In general, the bond market is volatile, and fixed income securities carry interest rate risk. (As interest rates rise, bond prices usually fall, and vice versa. This effect is usually more pronounced for longer-term securities.) Fixed income securities also carry inflation risk, liquidity risk, call risk, and credit and default risks for both issuers and counterparties. Unlike individual bonds, most bond funds do not have a maturity date, so holding them until maturity to avoid losses caused by price volatility is not possible.

The municipal market can be affected by adverse tax, legislative, or political changes, and by the financial condition of the issuers of municipal securities.

The securities of smaller, less well known companies can be more volatile than those of larger companies.

Some funds may use investment strategies involving derivatives and other transactions that may have a leveraging effect on the fund. Leverage can increase market exposure and magnify investment risk. Investors should be aware that there is no assurance that a fund's use of such strategies will succeed.

Leverage can magnify the impact of adverse issuer, political, regulatory, market, or economic developments on a company. In the event of bankruptcy, a company's creditors take precedence over its stockholders.

Changes in real estate values or economic conditions can have a positive or negative effect on issuers in the real estate industry.

​As with all your investments through Fidelity, and in connection with your evaluation of the security, you must make your own determination whether an investment in any particular security or securities is consistent with your investment objectives, risk tolerance, and financial situation. Fidelity is not recommending or endorsing this investment by making it available to its customers.

Past performance is no guarantee of future results.

Views expressed are as of the date indicated, based on the information available at that time, and may change based on market or other conditions. Unless otherwise noted, the opinions provided are those of the speaker or author and not necessarily those of Fidelity Investments or its affiliates. Fidelity does not assume any duty to update any of the information.

Fidelity Brokerage Services LLC, Member NYSE, SIPC, 900 Salem Street, Smithfield, RI 02917

1080901.28